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Health & Medicine

The body, disease, treatment and public health

Robert Koch at work with a microscope in his laboratory

Discovery of germ theory

The discovery of germ theory was the 19th-century recognition that specific microorganisms cause specific infectious diseases. It grew from the work of Ignaz Semmelweis, John Snow, Louis Pasteur and Robert Koch, and it replaced the older belief that disease arose from bad air. Background For most of history the dominant explanation was miasma theory, the

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The 19th-century finding that specific microbes cause infectious disease, built on the work of Semmelweis, Snow, Pasteur and Koch.

Colorized scanning electron micrograph of HIV-1 virus particles

Discovery of HIV

The discovery of HIV was the 1983 identification of the human immunodeficiency virus, the retrovirus that causes AIDS, by Françoise Barré-Sinoussi, Luc Montagnier and colleagues at the Pasteur Institute in Paris. It followed the first reports of the new immune deficiency syndrome in 1981 and was recognized with the 2008 Nobel Prize in Physiology or

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The 1983 identification of the human immunodeficiency virus, the cause of AIDS, by Barré-Sinoussi, Montagnier and colleagues at the Pasteur Institute.

Charles Best and Frederick Banting, co-discoverers of insulin, photographed in Toronto around 1924

Discovery of insulin

The discovery of insulin was the work done at the University of Toronto in 1921 and 1922 by Frederick Banting, Charles Best, John Macleod and James Collip. It produced a pancreatic extract that lowered blood sugar first in diabetic dogs and then in a human patient. The result turned type 1 diabetes from a fatal

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The 1921 to 1922 Toronto research by Banting, Best, Macleod and Collip that isolated insulin and first treated a diabetic patient.

Portrait painting of Alexander Fleming in a white coat at a desk in his laboratory, 1944

Discovery of penicillin

The discovery of penicillin began in 1928, when the Scottish bacteriologist Alexander Fleming noticed that a mold contaminating one of his staphylococcus cultures at St. Mary’s Hospital in London had killed the bacteria around it. The mold was Penicillium notatum, and the substance it released was named penicillin. It became a usable medicine only after

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The discovery of penicillin was Alexander Fleming's 1928 finding that a mold kills bacteria, developed into the first widely used antibiotic by Florey and Chain.

Sheep being held calm while a veterinarian draws blood for scrapie genetic resistance testing

Discovery of prions

The discovery of prions was the 1982 finding by Stanley Prusiner and his colleagues that a protein, with no detectable genetic material of its own, can act as an infectious agent that causes fatal brain diseases in animals and humans. He named the protein a prion, short for proteinaceous infectious particle, and received the 1997

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The 1982 finding by Stanley Prusiner that a misfolded protein with no nucleic acid can be an infectious agent causing fatal brain disease.

Oil painting by Eugene Ernest Hillemacher showing Edward Jenner vaccinating a boy against smallpox

Discovery of vaccination

The discovery of vaccination was the finding, made in England between 1774 and 1796, that deliberate exposure to cowpox protects people from smallpox. Benjamin Jesty carried out the first recorded vaccination in 1774, and Edward Jenner tested the idea systematically in 1796 and published it in 1801. Background Smallpox is one of the oldest known

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The 1774 to 1796 finding by Benjamin Jesty and Edward Jenner that exposure to cowpox protects against smallpox, which founded vaccination.

Headquarters of Médecins Sans Frontières in Geneva

Doctors Without Borders

Doctors Without Borders, known internationally as Médecins Sans Frontières (MSF), is an independent medical humanitarian organization that provides emergency health care to people affected by conflict, epidemics, disasters and exclusion from care. It was founded in Paris in 1971 by a group of doctors and journalists and received the Nobel Peace Prize in 1999. History

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Doctors Without Borders, or Médecins Sans Frontières, is an independent medical humanitarian organization founded in Paris in 1971.

A 12-lead electrocardiogram recording of a healthy adult

Electrocardiogram

An electrocardiogram (ECG, also written EKG) is a test that records the electrical signals the heart makes each time it beats. MedlinePlus, the health information service of the U.S. National Library of Medicine, describes it as a simple, painless and quick test. The recording appears as wavy lines with sharp spikes, and a trained clinician

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A painless test that records the heart's electrical signals with sensors on the skin, shown as wavy lines called waves.

John Snow's 1854 map tracing a London cholera outbreak to a contaminated water pump

Epidemiology

Epidemiology is the study of how diseases and other health events are distributed across populations, along with the factors that determine that distribution, with the ultimate goal of controlling health problems and improving public health. Rather than focusing on diagnosing or treating a single patient, epidemiologists examine patterns across groups of people, looking at who

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The study of how diseases and health events are distributed across populations and what drives that distribution.

Health workers vaccinating people during the smallpox and measles control program in Niger, West Africa, 1969

Eradication of smallpox

The eradication of smallpox was the worldwide public health campaign that ended natural transmission of the variola virus, which caused smallpox. The last known natural case occurred in Somalia in 1977, and the World Health Assembly declared the world free of the disease on May 8, 1980. According to the World Health Organization (WHO), it

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The global campaign, led by the World Health Organization, that ended natural smallpox transmission, declared complete in 1980.